I'm with
. I don't have a chronograph and I haven't had any problems. I just check my cases/primers for signs of "over pressure". .45acp is a low (comparatively) pressure cartridge. If you stay within the min. & max. parameters for your chosen bullet/powder combo, I think the only variable(s) you'd have to keep an eye on is not seating to bullet too deep and over crimping your case mouth.
Of course, I'm not a professional and haven't been reloading for 50 years. I'll get a chronograph soon because I want to start pushing my 10mm and 9x23 faster. I'm also just starting to reload .223. I begged my neighbor's chronograph to test those
Pay attention to what you're doing and religiously check your cases, you should be OK.